BCG vaccine produces a “trained immunity response” which lasts more than a year

The immune boosting benefits of a tuberculosis vaccine can be seen in infants more than one year after vaccination, according to a new study.

The research, led by the Murdoch Children’s Research Institute (MCRI) and published in Science Advances, has shown how the BCG vaccine, developed to prevent the risk of tuberculosis, can produce a ‘trained immunity response’ lasting more than 14 months after the vaccine is administered.

The randomized controlled trial involved 130 infants from the Melbourne Infant Study: BCG for the Prevention of Allergy and Infection (MIS BAIR) and cell dish models to study the immune system’s response to BCG vaccination. Those randomized to be vaccinated received their jab within 10 days of birth.

Murdoch Children’s Dr Samantha Bannister said 14 months after having the BCG vaccination they saw reprogramming, a process where genes were switched off or on, in a specific blood cell type, called the monocyte.

“The off-target effects of the BCG vaccine against a range of viruses are explained in part by the reprogramming of how your genes work in the monocyte due to environmental and behavioral factors,” she said. The reprogramming of monocytes, a cell previously thought to have no capacity for memory, leads to trained immunity.”

Murdoch Children’s Associate Professor Boris Novakovic said the off-target effects were first identified in Africa, where BCG vaccinated children had reduced overall death rates.

“The off-target effects in Africa were known to last more than a year, but previous studies looking at BCG-associated monocyte signatures only looked at one month and three months following vaccination in adults,” he said. For the first time we have shown how the BCG vaccine can have long-lasting effects on the immune system of infants.

“As babies are the main population given the BCG vaccine, this study is important because findings in adults do not always translate to children.”

For the trial the research team collaborated with the lab of Professor Mihai Netea from the Radboud University Medical Center in the Netherlands that first described trained immunity and scientists from the International Trained Immunity (INTRIM) Consortium.

Murdoch Children’s and University of Melbourne’s Professor Nigel Curtis said the next step was to see what impact this early trained immunity offered later in childhood and into adulthood.

Professor Curtis’ team at the Murdoch Children’s is leading the BRACE trial, the world’s largest examination of the off-target effects of the BCG vaccine in more than 6800 healthcare workers in Australia, Brazil, Spain, the Netherlands and the United Kingdom. BRACE is testing whether the vaccine can protect those exposed to SARS-CoV-2 from developing severe symptoms by boosting their frontline immunity.

Researchers from the University of Melbourne, The Royal Children’s Hospital, Radboud University Medical Center in The Netherlands, the Walter and Eliza Hall Institute of Medical Research and the University of Bonn in Germany also contributed to the findings.

Source:

Murdoch Childrens Research Institute

Journal reference:

Bannister, S., et al. (2022) Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes. Science Advances. doi.org/10.1126/sciadv.abn4002.

Baby News

Related Posts

Improving our understanding of a severe pregnancy sickness

Comments Off on Improving our understanding of a severe pregnancy sickness

New UC Davis study to track children’s exposure to chemicals in household dust

Comments Off on New UC Davis study to track children’s exposure to chemicals in household dust

Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

Comments Off on Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

Large U.S. study finds majority of mRNA COVID-19 side effects are mild and temporary

Comments Off on Large U.S. study finds majority of mRNA COVID-19 side effects are mild and temporary

Drought may affect child vaccination coverage in Africa, study finds

Comments Off on Drought may affect child vaccination coverage in Africa, study finds

Effective anti-vaping advertisements can have the greatest impact on teens

Comments Off on Effective anti-vaping advertisements can have the greatest impact on teens

Human milk immune activity may both lower and increase infants’ infectious disease risk

Comments Off on Human milk immune activity may both lower and increase infants’ infectious disease risk

Potential cause of racial disparity affecting infants with congenital heart disease discovered

Comments Off on Potential cause of racial disparity affecting infants with congenital heart disease discovered

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

Comments Off on Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

Outdoor Night Game Ideas for Kids and Teens

Comments Off on Outdoor Night Game Ideas for Kids and Teens

Butternut Squash Risotto – Super Healthy Kids

Comments Off on Butternut Squash Risotto – Super Healthy Kids

Study reveals a spike in hospital readmissions for pediatric asthma

Comments Off on Study reveals a spike in hospital readmissions for pediatric asthma

Create Account



Log In Your Account