Investigating the association between infertility and psychological distress using Australian Longitudinal Study on Women’s Health (ALSWH)

  • Starrs, A. M. et al. Accelerate progress-sexual and reproductive health and rights for all: Report of the Guttmacher-Lancet Commission. Lancet 391, 2642–2692. https://doi.org/10.1016/s0140-6736(18)30293-9 (2018).

    Article 
    PubMed 

    Google Scholar 

  • WHO. WHO fact sheet on infertility. Glob. Reprod. Health 6, e52. https://doi.org/10.1097/grh.0000000000000052 (2021).

    Article 

    Google Scholar 

  • Sun, H. et al. Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990–2017: Results from a global burden of disease study, 2017. Aging (Albany NY) 11, 10952–10991. https://doi.org/10.18632/aging.102497 (2019).

    Article 

    Google Scholar 

  • Evers, J. L. H. Female subfertility. Lancet 360, 151–159. https://doi.org/10.1016/S0140-6736(02)09417-5 (2002).

    Article 
    PubMed 

    Google Scholar 

  • Herbert, D. L., Lucke, J. C. & Dobson, A. J. Infertility, medical advice and treatment with fertility hormones and/or in vitro fertilisation: A population perspective from the Australian Longitudinal Study on Women’s Health. Aust. N. Z. J. Public Health 33, 358–364. https://doi.org/10.1111/j.1753-6405.2009.00408.x (2009).

    Article 
    PubMed 

    Google Scholar 

  • Gilbert, E. W., Boyle, J. A., Campbell, S. K. & Rumbold, A. R. Infertility in Aboriginal and Torres Strait Islander people: A cause for concern?. Aust. N. Z. J. Obstet. Gynaecol. 60, 479–481. https://doi.org/10.1111/ajo.13158 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Schanz, S. et al. Long-term life and partnership satisfaction in infertile patients: A 5-year longitudinal study. Fertil. Steril. 96, 416–421. https://doi.org/10.1016/j.fertnstert.2011.05.064 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Greil, A. L., Slauson-Blevins, K. & McQuillan, J. The experience of infertility: A review of recent literature. Sociol. Health Illn. 32, 140–162. https://doi.org/10.1111/j.1467-9566.2009.01213.x (2010).

    Article 
    PubMed 

    Google Scholar 

  • Gonzalez, L. O. Infertility as a transformational process: A framework for psychotherapeutic support of infertile women. Issues Ment. Health Nurs. 21, 619–633. https://doi.org/10.1080/01612840050110317 (2000).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Chachamovich, J. R. et al. Investigating quality of life and health-related quality of life in infertility: A systematic review. J. Psychosom. Obstet. Gynecol. 31, 101–110. https://doi.org/10.3109/0167482X.2010.481337 (2010).

    Article 

    Google Scholar 

  • Jacob, M. C., McQuillan, J. & Greil, A. L. Psychological distress by type of fertility barrier. Hum. Reprod. 22, 885–894. https://doi.org/10.1093/humrep/del452 (2007).

    Article 
    PubMed 

    Google Scholar 

  • Klemetti, R., Raitanen, J., Sihvo, S., Saarni, S. & Koponen, P. Infertility, mental disorders and well-being—A nationwide survey. Acta Obstet. Gynecol. Scand. 89, 677–682. https://doi.org/10.3109/00016341003623746 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Biringer, E., Howard, L. M., Kessler, U., Stewart, R. & Mykletun, A. Is infertility really associated with higher levels of mental distress in the female population? Results from the North-Trøndelag Health Study and the Medical Birth Registry of Norway. J. Psychosom. Obstet. Gynecol. 36, 38–45 (2015).

    Article 

    Google Scholar 

  • McQuillan, J., Greil, A. L., White, L. & Jacob, M. C. Frustrated fertility: Infertility and psychological distress among women. J. Marriage Fam. 65, 1007–1018 (2003).

    Article 

    Google Scholar 

  • Berg, B. J. & Wilson, J. F. Psychiatric morbidity in the infertile population: A reconceptualization. Fertil. Steril. 53, 654–661 (1990).

    CAS 
    Article 

    Google Scholar 

  • Fisher, J. R. W., Baker, G. H. W. & Hammarberg, K. Long-term health, well-being, life satisfaction, and attitudes toward parenthood in men diagnosed as infertile: Challenges to gender stereotypes and implications for practice. Fertil. Steril. 94, 574–580. https://doi.org/10.1016/j.fertnstert.2009.01.165 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Oddens, B. J., den Tonkelaar, I. & Nieuwenhuyse, H. Psychosocial experiences in women facing fertility problems—A comparative survey. Hum. Reprod. 14, 255–261. https://doi.org/10.1093/humrep/14.1.255 (1999).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Graham, M. L., Hill, E., Shelley, J. M. & Taket, A. R. An examination of the health and wellbeing of childless women: A cross-sectional exploratory study in Victoria, Australia. BMC Womens Health 11, 1–7. https://doi.org/10.1186/1472-6874-11-47 (2011).

    Article 

    Google Scholar 

  • Maximova, K. & Quesnel-VallĂŠe, A. Mental health consequences of unintended childlessness and unplanned births: Gender differences and life course dynamics. Soc. Sci. Med. 68, 850–857. https://doi.org/10.1016/j.socscimed.2008.11.012 (2009).

    Article 
    PubMed 

    Google Scholar 

  • Holton, S., Fisher, J. & Rowe, H. Motherhood: Is it good for women’s mental health?. J. Reprod. Infant Psychol. 28, 223–239. https://doi.org/10.1080/02646830903487359 (2010).

    Article 

    Google Scholar 

  • Widge, A. Sociocultural attitudes towards infertility and assisted reproduction in India. Curr. Pract. Controv. Assist. Reprod. 60, 74 (2002).

    Google Scholar 

  • Khan, A. R., Iqbal, N. & Afzal, A. Impact of Infertility on mental health of women. Int. J. Indian Psychol. 7(1), 804–809. https://doi.org/10.25215/0701.089 (2019).

    Article 

    Google Scholar 

  • Ramezanzadeh, F. et al. A survey of relationship between anxiety, depression and duration of infertility. BMC Womens Health 4, 9. https://doi.org/10.1186/1472-6874-4-9 (2004).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hasanpoor-Azghdy, S. B., Simbar, M. & Vedadhir, A. The emotional-psychological consequences of infertility among infertile women seeking treatment: Results of a qualitative study. Iran. J. Reprod. Med. 12, 131 (2014).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Herbert, D. L., Lucke, J. C. & Dobson, A. J. Depression: An emotional obstacle to seeking medical advice for infertility. Fertil. Steril. 94, 1817–1821. https://doi.org/10.1016/j.fertnstert.2009.10.062 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Mishra, G. D., Chung, H.-F. & Dobson, A. J. The current state of women’s health in Australia: Informing the development of the National Women’s Health Strategy 2020–2030. (Canberra, Australia, 2018).

  • Lee, C. et al. Cohort profile: The Australian Longitudinal Study on women’s health. Int. J. Epidemiol. 34, 987–991. https://doi.org/10.1093/ije/dyi098 (2005).

    Article 
    PubMed 

    Google Scholar 

  • Holden, L. et al. Mental Health: Findings from the Australian Longitudinal Study on Women’s Health (Australian Government Department of Health and Ageing, 2013).

    Google Scholar 

  • Rumpf, H.-J., Meyer, C., Hapke, U. & John, U. Screening for mental health: Validity of the MHI-5 using DSM-IV Axis I psychiatric disorders as gold standard. Psychiatry Res. 105, 243–253 (2001).

    CAS 
    Article 

    Google Scholar 

  • Holmes, W. C. A short, psychiatric, case-finding measure for HIV seropositive outpatients: Performance characteristics of the 5-item mental health subscale of the SF-20 in a male, seropositive sample. Med. Care 36, 237–243. https://doi.org/10.1097/00005650-199802000-00012 (1998).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Silveira, E. et al. Performance of the SF-36 health survey in screening for depressive and anxiety disorders in an elderly female Swedish population. Qual. Life Res. 14, 1263–1274. https://doi.org/10.1007/s11136-004-7753-5 (2005).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Andresen, E. M., Malmgren, J. A., Carter, W. B. & Patrick, D. L. Screening for depression in well older adults: Evaluation of a short form of the CES-D. Am. J. Prev. Med. 10, 77–84 (1994).

    CAS 
    Article 

    Google Scholar 

  • Goldberg, D., Bridges, K., Duncan-Jones, P. & Grayson, D. Detecting anxiety and depression in general medical settings. BMJ 297, 897–899. https://doi.org/10.1136/bmj.297.6653.897 (1988).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Remoteness, M. Accessibility/Remoteness Index of Australia (ARIA) (Commonwealth Department of Health and Aged Care 2, I, 2001).

    Google Scholar 

  • Ghisletta, P. & Spini, D. An introduction to generalized estimating equations and an application to assess selectivity effects in a longitudinal study on very old individuals. J. Educ. Behav. Stat. 29, 421–437. https://doi.org/10.3102/10769986029004421 (2004).

    Article 

    Google Scholar 

  • Costanza, M. C. & Afifi, A. Comparison of stopping rules in forward stepwise discriminant analysis. J. Am. Stat. Assoc. 74, 777–785 (1979).

    Article 

    Google Scholar 

  • Ezzell, W. The impact of infertility on women’s mental health. N. C. Med. J. 77, 427. https://doi.org/10.18043/ncm.77.6.427 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Agostini, F. et al. Assisted reproductive technology treatments and quality of life: A longitudinal study among subfertile women and men. J. Assist. Reprod. Genet. 34, 1307–1315. https://doi.org/10.1007/s10815-017-1000-9 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Daniluk, J. C. Reconstructing their lives: A longitudinal, qualitative analysis of the transition to biological childlessness for infertile couples. J. Couns. Dev. 79, 439–449. https://doi.org/10.1002/j.1556-6676.2001.tb01991.x (2001).

    Article 

    Google Scholar 

  • Riggs, D. W. & Bartholomaeus, C. The desire for a child among a sample of heterosexual Australian couples. J. Reprod. Infant Psychol. 34, 442–450. https://doi.org/10.1080/02646838.2016.1222070 (2016).

    Article 

    Google Scholar 

  • Wilkes, S. & Fankam, F. Review of the management of female infertility: A primary care perspective. Clin. Med. Rev. Women’s Health 2010, 11–23 (2010).

    Google Scholar 

  • Tabong, P.T.-N. & Adongo, P. B. Infertility and childlessness: a qualitative study of the experiences of infertile couples in Northern Ghana. BMC Pregnancy Childbirth 13, 72. https://doi.org/10.1186/1471-2393-13-72 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sembuya, R. Mother or nothing: the agony of infertility. Bull. World Health Organ. 88, 881–882 (2010).

    Article 

    Google Scholar 

  • Stellar, C., Garcia-Moreno, C., Temmerman, M. & van der Poel, S. A systematic review and narrative report of the relationship between infertility, subfertility, and intimate partner violence. Int. J. Gynecol. Obstet. 133, 3–8. https://doi.org/10.1016/j.ijgo.2015.08.012 (2016).

    Article 

    Google Scholar 

  • Schmidt, L., Christensen, U. & Holstein, B. The social epidemiology of coping with infertility. Hum. Reprod. 20, 1044–1052. https://doi.org/10.1093/humrep/deh687 (2005).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Galhardo, A., Cunha, M. & Pinto-Gouveia, J. Psychological aspects in couples with infertility. Sexologies 20, 224–228 (2011).

    Article 

    Google Scholar 

  • Chambers, G. M., Hoang, V. & Illingworth, P. J. Socioeconomic disparities in access to ART treatment and the differential impact of a policy that increased consumer costs. Hum. Reprod. 28, 3111–3117. https://doi.org/10.1093/humrep/det302 (2013).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Peterson, B. D. et al. The longitudinal impact of partner coping in couples following 5 years of unsuccessful fertility treatments. Hum. Reprod. 24, 1656–1664. https://doi.org/10.1093/humrep/dep061 (2009).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Scott, K. M. et al. Obesity and mental disorders in the general population: Results from the world mental health surveys. Int. J. Obes. (Lond.) 32, 192–200. https://doi.org/10.1038/sj.ijo.0803701 (2008).

    CAS 
    Article 

    Google Scholar 

  • Boutari, C. et al. The effect of underweight on female and male reproduction. Metabolism 107, 154229. https://doi.org/10.1016/j.metabol.2020.154229 (2020).

    CAS 
    Article 
    PubMed 

    Google Scholar 

  • Talmor, A. & Dunphy, B. Female obesity and infertility. Best Pract. Res. Clin. Obstet. Gynaecol. 29, 498–506. https://doi.org/10.1016/j.bpobgyn.2014.10.014 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Sharma, R., Biedenharn, K. R., Fedor, J. M. & Agarwal, A. Lifestyle factors and reproductive health: Taking control of your fertility. Reprod. Biol. Endocrinol. 11, 66. https://doi.org/10.1186/1477-7827-11-66 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Esmaeilzadeh, S., Delavar, M. A., Basirat, Z. & Shafi, H. Physical activity and body mass index among women who have experienced infertility. Arch. Med. Sci. 9, 499–505. https://doi.org/10.5114/aoms.2013.35342 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Logan, S., Perz, J., Ussher, J. M., Peate, M. & Anazodo, A. Systematic review of fertility-related psychological distress in cancer patients: Informing on an improved model of care. Psychooncology 28, 22–30. https://doi.org/10.1002/pon.4927 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Direkvand-Moghadam, A., Delpisheh, A. & Khosravi, A. Epidemiology of female infertility; A review of literature. Biosci. Biotechnol. Res. Asia 10, 559–567. https://doi.org/10.13005/bbra/1165 (2013).

    CAS 
    Article 

    Google Scholar 

  • Ying, L. Y., Wu, L. H. & Loke, A. Y. Gender differences in experiences with and adjustments to infertility: A literature review. Int. J. Nurs. Stud. 52, 1640–1652. https://doi.org/10.1016/j.ijnurstu.2015.05.004 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Himelein, M. J. & Thatcher, S. S. Polycystic ovary syndrome and mental health: A review. Obstet. Gynecol. Surv. 61, 723–732. https://doi.org/10.1097/01.ogx.0000243772.33357.84 (2006).

    Article 
    PubMed 

    Google Scholar 

  • Brutocao, C. et al. Psychiatric disorders in women with polycystic ovary syndrome: A systematic review and meta-analysis. Endocrine 62, 318–325. https://doi.org/10.1007/s12020-018-1692-3 (2018).

    CAS 
    Article 
    PubMed 

    Google Scholar