Most children and adolescents with cancer have mild COVID-19 disease and make a full recovery, a new study has found. But pediatric cancer patients with underlying health conditions, severe infections and low white blood cell counts were significantly more likely to have severe disease.
The study, led by the Murdoch Children’s Research Institute (MCRI), Peter MacCallum Cancer Centre and Goethe University in Frankfurt, which provides new insights into COVID-19 disease severity, duration of shedding, symptoms and outcomes in children with cancer, will help inform treatment decisions.
The research, published in the European Journal of Cancer, involved 131 children aged under 19 years with COVID-19 across 10 countries including Australia, Germany, Brazil and Canada. The participants either had a diagnosis of cancer or had undergone a bone marrow stem cell transplant.
MCRI and Peter MacCallum Cancer Centre Associate Professor Gabrielle Haeusler said there was limited data before this study on SARS-CoV-2 infection in children with cancer or stem cell transplants.
The study reported a third of patients were asymptomatic with 47 per cent overall having mild cases, 8 per cent moderate cases, 4 per cent severe and 9 per cent critical. It found 37 per cent were hospitalised, 11 per cent required ICU care and four died due to COVID-19. But in 95 per cent of cases the patients made a full recovery.
Associate Professor Haeusler, also a physician at The Royal Children’s Hospital, said increased COVID-19 severity in children with cancer was detected in those with co-morbidities, severe infections (mostly bacterial co-infections) and low white blood cell counts, a marker of immune suppression, emphasising the need for a heightened awareness among healthcare staff.
For patients on active treatment, chemotherapy was delayed or doses were modified in a third of cases. Importantly, changes in treatment were not significantly associated with a reduced risk of severe COVID-19. There was no difference in the proportion of patients with symptomatic infection who were having cancer treatment and those had completed treatment.
The most frequent COVID-19 symptoms were fever, cough, runny nose and gastro. The median duration of virus detection in the patients was 16 days. However, the virus was detected up to 80 days after initial infection in some patients.
Goethe University Professor Thomas Lehrnbecher said the COVID-19 pandemic had posed great challenges for patients with cancer.
“While data emerged early in the pandemic about the increased risks of worse outcomes and death for adult cancer patients with COVID-19, the impact of the disease in children with cancer was less clear,” he said
“An understanding of the impact of COVID-19 in children with cancer is critical to informing paediatric care pathways including modifying chemotherapy regimens and isolation restrictions.”
Children over 12 years with cancer or a history of cancer are a priority group for an mRNA COVID-19 vaccine.
Associate Professor Haeusler said while the study identified some predictors of severe illness, prevention was still our best defence.
“We found most COVID-19 transmissions occurred within the family home. In addition to the vaccination of treating healthcare workers, vaccination of household and regular family contacts against COVID-19 is a crucial protective measure,” she said.
“Ongoing surveillance is also critical to monitor vaccine efficacy and impact of emerging COVID-19 variants in this vulnerable population.”
Murdoch Childrens Research Institute
Gabrielle M Haeusler, Roland A Ammann, Fabianne Carlesse, Andreas H Groll, Dina Averbuch, Elio Castagnola, Philipp KA Agyeman, Bob Phillips, Flávio Gilli, Galina Solopova, Andishe Attarbaschi, Oliver Wegehaupt, Carsten Speckmann, Lillian Sung and Thomas Lehrnbecher. ‘SARS-CoV-2 in Children with Cancer or Following Haematopoietic Stem Cell Transplant: An Analysis of 131 Patients,’ European Journal of Cancer. DOI: 10.1016/j.ejca.2021.09.027