Nutritionally modified formula milk not associated with improved academic performance

Babies who were given nutritionally modified formula milk had the same maths and English exam results as children who were given standard formula milk by age 16, finds a major new study led by UCL researchers that links seven randomized controlled trials to school performance results.

Scientists from the UCL Great Ormond Street Institute of Child Health (GOS ICH) and the UCL Institute of Education, who published their findings in the BMJ today, used a novel approach to link school performance and health data to see whether nutritionally modified formula milk made any difference to later cognitive ability.

The research team analyzed data from 1763 children who were participating in trials between 1993 and 2001 and were randomly given either enriched or standard formula milk. Randomization ensured that the groups were equal in all ways apart from the type of formula milk they received.

The researchers then gathered anonymized data for 91% (1607) of the children from their school records at age 11 and 16 to see if the type of milk they had been given as babies had a noticeable effect on their school performance.

Two of the trials tested formula milks which had been enriched with a long chain polyunsaturated fatty acid (LCPUFA), one of the many breast milk constituents with a role in brain development. Another trial tested follow-on formula with high-iron content and two tested nutrient enriched formula milks. A further two tested formulations with added sn-2 palmitate or nucleotides, but these were not thought to relate to cognition.

Data from the trials was linked to school records and showed that there was no benefit on scores for national exams in maths at age 16 years (GCSEs).  At age 11, children who had been given the LCPUFA supplemented formula scored lower in both English and maths, but this could not be confirmed at age 16 years. None of the other modified formulas led to improved performance in English at age 16 and in maths and English at age 11 years (Key Stage 2) or affected eligibility for special educational needs support and achieving five or more GCSE grades of C or higher.

Our findings suggest there are no long-term benefits of these modified formula milks on brain development. Regulators should use these findings to reconsider licensing which modifications of formula milks are approved and to ensure that labeling of products excludes unproven claims.”

Ruth Gilbert, Co-Author, Professor, UCL Great Ormond Street Institute of Child Health

The researchers note that although the trials were carried out several decades ago but are relevant to formula milks used today. However, new types of formula are being developed. This study shows how linkage to education data could make long-term follow up of cognition much easier for future and past formula trials.

Lead author Dr Maximiliane Verfürden, who carried out the research at the UCL Great Ormond Street Institute of Child Health, added: “No previous research has shown conclusive benefits for cognitive ability of these nutritionally modified formulas, but the evidence was uncertain due to short follow-up periods and high drop-out rates over time

“By linking data from historic randomized trials to data routinely collected from school tests, the current study provides the best available evidence on whether these formula modifications affect children’s cognitive ability.

“This study sets a precedent for other trials and cohorts to use linkage of historic trials to administrative data to address high participant drop-out over time and answer important questions about long term outcomes in children and young people.”

The study was supported with funding from the Economic and Social Research Council, UCL Bloomsbury and East London Doctoral Training Partnership, Great Ormond Street Hospital Charity Research Starter Grant, NIHR Children and Families Policy Research Unit and Health Data Research UK.

Source:

University College London

Baby News

Related Posts

COVID-19 disruptions affect one sibling more than the other in multi-child families

Comments Off on COVID-19 disruptions affect one sibling more than the other in multi-child families

Immune fitness plays a vital role in pandemic preparedness

Comments Off on Immune fitness plays a vital role in pandemic preparedness

Study may provide a better understanding of the interplay between brain networks in autism

Comments Off on Study may provide a better understanding of the interplay between brain networks in autism

CHOP and Penn Medicine join hands to address environmental hazards and protect vulnerable children

Comments Off on CHOP and Penn Medicine join hands to address environmental hazards and protect vulnerable children

Study finds high level of resilience among children and adolescents living with glaucoma

Comments Off on Study finds high level of resilience among children and adolescents living with glaucoma

Researchers call for new focus on support for children’s positive health development and well-being

Comments Off on Researchers call for new focus on support for children’s positive health development and well-being

How to protect your kids from dog bites – CHOC

Comments Off on How to protect your kids from dog bites – CHOC

Maternal antibodies may play a key role in protecting infants from congenital HCMV infections

Comments Off on Maternal antibodies may play a key role in protecting infants from congenital HCMV infections

Antibody combination produces a synergistic response in difficult-to-treat pediatric cancers

Comments Off on Antibody combination produces a synergistic response in difficult-to-treat pediatric cancers

Does my child have a strain, sprain or break? – CHOC

Comments Off on Does my child have a strain, sprain or break? – CHOC

Acetaminophen vs. ibuprofen: A guide for parents – CHOC

Comments Off on Acetaminophen vs. ibuprofen: A guide for parents – CHOC

Findings Explain Exceptional Auditory Abilities In Williams-Beuren Syndrome

Comments Off on Findings Explain Exceptional Auditory Abilities In Williams-Beuren Syndrome

Create Account



Log In Your Account