Unilateral Twin Ectopic Pregnancy: A Case Report from the Eastern Part

Introduction: Twin ectopic pregnancy is the implantation of both embryos outside of the endometrial lining occurring in 1 in 20,000 up to 1 in 125,000 pregnancies. Commonly, twin ectopic pregnancies occur inside the fallopian tube either unilateral or bilateral. Unless early diagnosis and interventions are made, it may rupture causing intraperitoneal bleeding with a high risk of maternal death.
Case Report: I am reporting a rare type of ectopic pregnancy: unilateral twin ectopic pregnancy with positive cardiac activity on the left side of the fallopian tube in a 30 years old gravida III para II mother. Left side salpingectomy was done for her and discharged from the hospital after two postoperative days.
Conclusion: Twin ectopic pregnancy with a live embryo is a very rare type of pregnancy that needs a high index of suspicion to diagnose and treat early to prevent complications and maternal death.


Two embryos or blastocysts implanting outside of the uterine cavity is known as a twin ectopic pregnancy. Though it may implant in other locations, the twin ectopic often implants in the fallopian tube. Ectopic pregnancies are typically discovered after tubal rupture in low-income countries; which is associated with the high rate of maternal mortality and morbidity unless they are identified and treated timely. Twin ectopic pregnancies are harder to identify than singleton ectopic pregnancies, and they are also more dangerous for the mother and have higher rates of morbidity and mortality. Because of this, preventing morbidity and death requires early identification and treatment.

Case Description

A 30 years old gravida III para II (both by cesarean section and alive), whose gestational age from her last menstrual period was 6 weeks plus five days presented with the chief complaint of lower abdominal and back pain of one-week duration. Other than the pain, she had no vaginal bleeding, blurring of vision, tinnitus, vertigo, headache, nausea, or vomiting. She never had a history of sexually transmitted diseases or infertility treatment. Except for the two cesarean sections, she never had other types of abdominopelvic surgeries.

On physical examination, her vital sign was stable with Blood Pressure =125/82mmhg, Pulse Rate = 84bpm, Respiratory Rate = 18, and Temperature = 36.9°C.

On Abdominal examination; the abdomen was flat, moving with respiration, soft and non-tender. There was no sign of fluid collection (no fluid thrill or shifting dullness). Bimanual pelvic examination indicates that the uterine size was 8 weeks sized with left side adnexal mass. She also had left adnexal and cervical motion tenderness. For this, both abdominal and transvaginal ultrasound were performed showing an empty uterus, with normal endometrial echo and thickness (Figure 1). On the left side of the adnexa, there were two gestational sacs with their yolk sac and fetal embryo separated by a thick intertwin membrane (Figure 2). In both of the embryos, cardiac activity was seen on color Doppler flow (Figure 3). In addition, the following laboratory requests were performed with results of; Complete Blood Count; Hemoglobin = 13.5g/dl, White Blood Cell = 8.69 × 103 /ul, the platelet count was 236 × 103, and serum HCG value was 86,456.00. Urine analysis and sexually transmitted tests were unremarkable.

Figure 1 Transvaginal ultrasound showing an empty uterus.

Figure 2 Transvaginal ultrasound. (A) Two gestational sacs. (B) Embryo in each of both gestational sac.

Figure 3 Demonstrating one of the embryos with positive cardiac activity on color Doppler.

Using the above evidence, a diagnosis of unilateral live twin ectopic pregnancy was made and laparotomy was decided. After taking informed consent and preparing for laparotomy, she was taken to the operation theater. Under general anesthesia, the abdomen was entered through a Pfannenstiel incision (through the previous 2 cesarean section scars). Upon entry into the abdomen, there was dense adhesion between the abdominal wall and uterus, 3cm by 4cm intact left intact ampulla (tubal) ectopic pregnancy (Figure 4). After adhesion was released, left side salpingectomy was performed and the abdomen was closed in layers. Dissecting the resected tube shows two separate gestational sacs (Figure 5). The woman was discharged home after two smooth post-operative days in the hospital.

Figure 4 Left tubal ectopic pregnancy after adhesiolysis.

Figure 5 Resected tube with two gestational sacs.


Ectopic pregnancy is the implantation of the embryo outside of the endometrial cavity with an incidence of 1–2% among all types of pregnancies.1 The most common site of implantation outside the endometrial lining is tubal accounting for more than 90% of the cases. The other sites of implantation include: ovarian, cervical, abdominal, cesarean scar, or interstitial.

Ectopic pregnancies are commonly singleton with rare findings of twin ectopic pregnancy occurring in 1:20,000 up to 1:125,000 pregnancies. One ectopic pregnancy can happen with one intrauterine (heterotopic) or the other with molar pregnancy.1–3

Twin ectopic pregnancy is the implantation of both embryos outside of the endometrial lining; it can implant commonly on tubes but there are reports of twin ectopic implanted on the ovary,4 abdominal,5 cesarean scar,6 cornual7 and cervical.8 Different case reports indicate that there are twins with or without cardiac activity. In cases of tubal twin pregnancies, reports showed the majority are unilateral tubal pregnancies while few are bilateral tubal pregnancies.3,9–12 In this woman, the implantation was on the left side of the uterine tube with both positive cardiac activities.

Even though half of the ectopic pregnancies has no predisposing or risk factors, most risk factors associated with singleton or twin ectopic pregnancy are previous history of ectopic pregnancy, sexually transmitted infection/Pelvic inflammatory disease, previous tubal surgery, invitro fertilization, ovulation inducing drugs like clomiphene citrate, smoking, advanced maternal age, failed contraception use or previous cesarean section.1,8,13–15 In this case, except for the two cesarean sections that may increase the risk of cesarean scar ectopic not tubal, she has no well-known risk factors.

The clinical features of twin ectopic pregnancy are similar to singleton ectopic pregnancy which is, triad of amenorrhea, vaginal bleeding and abdominal pain.1 After the ectopic has ruptured, individuals may exhibit abnormal vital signs, acute abdominal symptoms, and anemia-related signs and symptoms. Amenorrhea and abdominal pain are present in this patient, but there is no vaginal bleeding. The likelihood of an unruptured ectopic pregnancy is increased by the absence of any peritoneal or diaphragmatic irritation. The risk of rupture in tubal ectopic pregnancy is higher in twin unilateral tubal pregnancy than singleton tubal pregnancy occurring in 30–50% of cases.10,16

Diagnosis of twin ectopic pregnancy depends on the clinical feature, laboratory tests and imaging. The definitive diagnosis will be made by demonstration of two alive cardiac activity fetuses outside of the uterus using sonography or confirmation of removed tissue by laparoscopy or laparotomy using pathologic evaluation. The serum HCG of the twin ectopic pregnancy is higher than the same gestational age of singleton ectopic or intrauterine pregnancy.4–6 Using transvaginal ultrasound is more sensitive and specific than transabdominal ultrasound. With ultrasound, we can visualize two gestational sac with or without separating membrane, or fetal cardiac activity.6,17–21 In difficult cases, we can use MRI to diagnose twin ectopic pregnancy.22

Management of the twin ectopic pregnancy is similar to the singleton ectopic pregnancy and depends on the site of implantation. These can be medical or surgical treatments. The medical treatments include intra-gestational feticidal, use of the methotrexate either systemic or intra-gestation. In some case reports there was a shift from medical to surgical after it failed. Surgical management used for the treatment of twin ectopic are hysteroscopic resection (used for cesarean sac twin ectopic), laparoscopic or laparotomy resection. Laparoscopically and by laparotomy salpingectomy, linear salpingostomy can be performed. Currently, arterial embolization is also used for twin ectopic pregnancy and found to be effective.3,16,17,19,23–25 In this case, laparotomy was done since there is no laparoscopy in the area and medical was not preferred since there was cardiac activity and poor adherence to it.


An extremely uncommon type of pregnancy called twin ectopic pregnancy has a substantial risk of maternal morbidity and mortality after the ectopic site ruptures. Ectopic pregnancy, especially twin ectopic, requires prompt identification and therapy in order to reduce morbidity and mortality.

Patient Consent

Written consent has been obtained from the patient after she has seen the detailed description of the case and the pictures to be published. No institutional approval was required for the publishing of this case report.


I want to thank the patient for giving me consent to publish.


No grant support or funding was given.


The author reports no conflicts of interest in this work.


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